Sandwell and West Birmingham NHS Trust

SONATA - Transforming Ovarian cancer diagnostic pathways (TranSforming Ovarian caNcer diAgnosTic pAthways: A hybrid Type 1 effectiveness-implementation study of a novel biomarker based, threshold driven pathway for earlier ovarian cancer diagnosis)

Ovarian cancer is often diagnosed at a late stage, making early detection crucial for improving outcomes. Currently, the standard approach in the NHS involves a two-step testing process: measuring CA125 levels in a blood test, followed by an ultrasound scan if CA125 levels are high. In secondary care, a test called the Risk of Malignancy Index (RMI) is used, which combines CA125 and ultrasound findings. However, recent evidence suggests that an alternative test, called the Risk of Ovarian Malignancy Algorithm (ROMA), may be more effective. ROMA combines CA125 with another biomarker, HE4, and could help improve early diagnosis.

The SONATA project aims to evaluate how ROMA can be implemented in primary care to improve ovarian cancer detection. The project will test ROMA across multiple NHS settings, including GP practices and hospitals, and assess its impact on diagnosis and referral processes. It will also include a community awareness campaign to ensure that women, particularly in underserved areas, are aware of ovarian cancer symptoms and testing options.

By integrating ROMA into the diagnostic pathway, SONATA hopes to improve early detection, streamline referrals, and reduce unnecessary tests, ultimately benefiting both patients and the healthcare system

The SONATA project aims to improve the early detection of ovarian cancer by evaluating the use of the Risk of Ovarian Malignancy Algorithm (ROMA) in primary and secondary care. By implementing ROMA across NHS settings, the project seeks to improve referral accuracy, reduce unnecessary tests, and streamline the diagnostic process.

27/12/2024

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