NHS Blood and Transplant

Factors Predicting Serum HLA Antibody Persistence or Decline in Kidney Transplant Patients on the Waiting List

Factors predicting serum HLA antibody persistence or decline in kidney transplant patients on the waiting list. The primary objective of this project is to predict what happens to kidney transplant waiting list patients’ HLA antibodies with time, which would help with patient management. The experimental approach will be to classify waiting list patient’s DSA dynamics and correlate this with clinical, demographic and other patient characteristics using machine learning (ML) and data modelling algorithms.

This research project investigates the dynamics of donor-specific HLA antibodies (DSA) in kidney transplant patients awaiting transplantation. The primary aim is to develop a predictive tool that identifies whether patients' HLA antibodies are likely to persist or decline over time. This information is crucial for optimising patient management and improving the chances of successful transplantation for highly sensitised patients—those with high levels of HLA antibodies who face longer waiting times and fewer compatible donor options.

25/07/2024

SDE014

West Midlands SDE trusted research environment

hra.nhs.uk